Xem mã nguồn của CLSTN1

{{Infobox gene}}
'''[[Calsyntenin]]-1''' là [[protein]] ở người được mã hóa bởi [[gen]] ''CLSTN1''.<ref name="pmid10048485">{{chú thích tạp chí | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="entrez">{{chú thích web | title = Entrez Gene: CLSTN1 calsyntenin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22883| access-date = }}</ref>

== Ý nghĩa lâm sàng ==
Đột biến trên gen CLSTN1 thể hiện sự tương quan với cơ chế phát [[bệnh Alzheimer]].<ref name="doi.10.1093/hmg/dds109">{{chú thích tạp chí | vauthors = Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC | title = Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production | journal = Human Molecular Genetics | volume = 21 | issue = 13 | pages = 2845–54 | date = Jul 2012 | pmid = 22434822 | doi = 10.1093/hmg/dds109 | pmc=3373235}}</ref>

== Tương tác ==
CLSTN1 có khả năng [[Tương tác protein-protein|tương tác]] với [[APBA2]]<ref name=pmid12972431>{{chú thích tạp chí | vauthors = Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T | title = Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-12-05_278_49/page/49448 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49448–58 | date = Dec 2003 | pmid = 12972431 | doi = 10.1074/jbc.M306024200 }}</ref><ref name=pmid15037614>{{chú thích tạp chí | vauthors = Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T | title = Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation | url = https://archive.org/details/sim_journal-of-biological-chemistry_2004-06-04_279_23/page/24342 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24343–54 | date = Jun 2004 | pmid = 15037614 | doi = 10.1074/jbc.M401925200 }}</ref> và [[protein tiền chất tinh bột]] (amyloid precursor protein).<ref name=pmid12972431/><ref name=pmid15037614/>

== Tham khảo ==
{{tham khảo}}

==Liên kết ngoài==
* {{UCSC gene info|CLSTN1}}
* {{UCSC gene info|PIK3CD}}

== Đọc thêm ==
{{refbegin|2}}
* {{chú thích tạp chí | vauthors = Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermühle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P | title = Calsyntenin-1 docks vesicular cargo to kinesin-1 | journal = Molecular Biology of the Cell | volume = 17 | issue = 8 | pages = 3651–63 | date = Aug 2006 | pmid = 16760430 | pmc = 1525238 | doi = 10.1091/mbc.E06-02-0112 }}
* {{chú thích tạp chí | vauthors = Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA | title = Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues | url = https://archive.org/details/sim_nature-biotechnology_2004-06_22_6/page/724 | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 724–31 | date = Jun 2004 | pmid = 15146195 | doi = 10.1038/nbt969 }}
* {{chú thích tạp chí | vauthors = Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T | title = Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation | url = https://archive.org/details/sim_journal-of-biological-chemistry_2004-06-04_279_23/page/24342 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24343–54 | date = Jun 2004 | pmid = 15037614 | doi = 10.1074/jbc.M401925200 }}
* {{chú thích tạp chí | vauthors = Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T | title = Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism | url = https://archive.org/details/sim_journal-of-biological-chemistry_2003-12-05_278_49/page/49448 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49448–58 | date = Dec 2003 | pmid = 12972431 | doi = 10.1074/jbc.M306024200 }}
* {{chú thích tạp chí | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = Nov 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
* {{chú thích tạp chí | vauthors = Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P | title = Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain | journal = Molecular and Cellular Neurosciences | volume = 17 | issue = 1 | pages = 151–66 | date = Jan 2001 | pmid = 11161476 | doi = 10.1006/mcne.2000.0937 }}
* {{chú thích tạp chí | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | url = https://archive.org/details/sim_gene_1997-10-24_200_1-2/page/149 | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{chú thích tạp chí | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | url = https://archive.org/details/sim_gene_1994-01-28_138_1-2/page/171 | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
{{refend}}

[[Thể loại:Protein người]]
[[Thể loại:Gen theo nhiễm sắc thể ở người]]
[[Thể loại:Gen trên nhiễm sắc thể 1 ở người]]


{{gene-1-stub}}